Although duodenal pancreatic invasion due to right colon cancer is extremely rare, this condition represents a challenge for the surgeon. While block resection is often the first therapeutic approach, the complexity of those malignant neoplasms of the colon that infiltrate and form fistulas in the duodenum or pancreas, accompanied by the scarce information on the subject, are high points that question such clínicomplex approaches such as block resections with pancreatoduodenectomy. Therefore, we report an unusual case of a perforated coloduodenal fistula in a patient with breast and colon cancer who required emergency multiorgan resection by right hemicolectomy and pancreatoduodenectomy in a block with delayed enteric tract reconstruction.